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Who was studied 45,352 European ancestry cases, 1,938,877 European ancestry controls.
The effect
Each copy of the G allele shifted the measure 0.025 higher (95% confidence interval 0.017-0.033); p = 8 × 10−11.
How common The G allele had a frequency of about 68% in the people studied.
Where it sits Chromosome 7, band 7p14.2 — in an intron of TBX20.
What each result means
A/ANo copy of the version the research linked to Aortic stenosis. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Aortic stenosis. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Aortic stenosis. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2026 · PMID 41419685 · open access
Questions about rs1833126
What is rs1833126?
rs1833126 is a single position in the genome, in or near the TBX20 gene. Published research associates it with aortic stenosis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1833126 linked to?
On MyGeneLog this position is linked to Aortic Stenosis. The research behind each link, and its sources, are set out on that condition page.
Does having rs1833126 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1833126 come from?
GWAS Catalog, Nature genetics 2026, PMID:41419685. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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