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Its strongest genetic-study result is p = 10−14, with 4 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 94,595 European ancestry individuals; replicated in 93,982 European ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.033 mg/dL lower; p = 2 × 10−12.
How common The G allele had a frequency of about 18% in the people studied.
Where it sits Chromosome 10, band 10p15.1 — in an intron of AKR1C4.
How common each version is
AG
KoreanKRGDB
A 90.8% · G 9.2%
KoreanKorea4K
A 91.2% · G 8.8%
KoreanKorea1K
A 91.6% · G 8.4%
Japanese ToMMo
A 91.5% · G 8.5%
Vietnamese
A 87.0% · G 13.0%
World gnomAD
A 88.7% · G 11.3%
World 1000 Genomes
A 89.8% · G 10.2%
World TOPMed
A 88.6% · G 11.4%
The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.
What each result means
A/ANo copy of the version the research linked to Triglycerides. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Triglycerides. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Triglycerides. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2013 · PMID 24097068 · open access
Questions about rs1832007
What is rs1832007?
rs1832007 is a single position in the genome, in or near the AKR1C4 gene. Published research associates it with triglycerides. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1832007 linked to?
On MyGeneLog this position is linked to High Triglycerides. The research behind each link, and its sources, are set out on that condition page.
Does having rs1832007 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1832007 come from?
GWAS Catalog, Nat Genet 2013, PMID:24097068. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license