Standard
Aortic valve stenosis
TEX41 · rs1830321
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What each result means
C/C
Published research associates this genotype with typical/baseline likelihood of Aortic valve stenosis — no copies of the reported risk allele.
C/T
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Aortic valve stenosis.
T/T
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Aortic valve stenosis compared to the general population.
Source
Genome-wide analysis yields new loci associating with aortic valve stenosis
Helgadottir A,
Thorleifsson G,
Gretarsdottir S,
Stefansson OA,
Tragante V,
Thorolfsdottir RB,
Jonsdottir I,
Bjornsson T,
Steinthorsdottir V,
Verweij N,
Nielsen JB,
Zhou W
and 34 more — show all
Folkersen L,
Martinsson A,
Heydarpour M,
Prakash S,
Oskarsson G,
Gudbjartsson T,
Geirsson A,
Olafsson I,
Sigurdsson EL,
Almgren P,
Melander O,
Franco-Cereceda A,
Hamsten A,
Fritsche L,
Lin M,
Yang B,
Hornsby W,
Guo D,
Brummett CM,
Abecasis G,
Mathis M,
Milewicz D,
Body SC,
Eriksson P,
Willer CJ,
Hveem K,
Newton-Cheh C,
Smith JG,
Danielsen R,
Thorgeirsson G,
Thorsteinsdottir U,
Gudbjartsson DF,
Holm H,
Stefansson K
Nature communications · 2018 · PMID 29511194 · open access
Questions about rs1830321
What is rs1830321?
rs1830321 is a single position in the genome, in or near the TEX41 gene. Published research associates it with aortic valve stenosis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs1830321 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1830321 come from?
GWAS Catalog, Nat Commun 2018, PMID:29511194. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
← See all variants