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Leucine levels

MAPK10 · rs182928083

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 115,078 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.183 lower (95% confidence interval 0.13-0.24); p = 2 × 10⁻¹⁰.

How common The G allele had a frequency of about 99% in the people studied.

Where it sits Chromosome 4, band 4q21.3 — in an intron of MAPK10.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Leucine levels — no copies of the reported risk allele.

C/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Leucine levels.

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Leucine levels compared to the general population.

Source

Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation

Richardson TG, Leyden GM, Wang Q, Bell JA, Elsworth B, Davey Smith G, Holmes MV

PLoS biology · 2022 · PMID 35213538 · open access

Questions about rs182928083

What is rs182928083?

rs182928083 is a single position in the genome, in or near the MAPK10 gene. Published research associates it with leucine levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs182928083 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs182928083 come from?

GWAS Catalog, PLoS biology 2022, PMID:35213538. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Leucine levels (rs182928083). MyGeneLog™. https://www.mygenelog.com/variants/rs182928083

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