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Arrhythmogenic cardiomyopathy

DSG4 · rs182626537

What the study found

Who was studied 104 Japanese ancestry cases, 46,527 Japanese ancestry controls.

The effect Each copy of the G allele carried 31.50 times the odds of Arrhythmogenic cardiomyopathy (95% confidence interval 19.2-51.9); p = 2 × 10−42.

How common The G allele had a frequency of about 1% in the people studied.

Where it sits Chromosome 18, band 18q12.1 — in an intron of DSG4.

What each result means

A/A No copy of the version the research linked to Arrhythmogenic cardiomyopathy. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Arrhythmogenic cardiomyopathy. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Arrhythmogenic cardiomyopathy. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs182626537

What is rs182626537?

rs182626537 is a single position in the genome, in or near the DSG4 gene. Published research associates it with arrhythmogenic cardiomyopathy. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs182626537 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs182626537 come from?

GWAS Catalog, Journal of arrhythmia 2026, PMID:41607864. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Arrhythmogenic cardiomyopathy (rs182626537). MyGeneLog™. https://www.mygenelog.com/variants/rs182626537

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