WDR1 · rs182603736
Where this position leads
Condition: Gout
What the study found
Who was studied 342,087 European ancestry individuals, 6,011 African ancestry individuals, 7,328 South Asian ancestry individuals.
The effect Each copy of the A allele shifted the measure 0.264 lower (95% confidence interval 0.21-0.32); p = 3 × 10−20.
Where it sits Chromosome 4, band 4p16.1 — a missense change in WDR1.
What ClinVar records
Classification
Conflicting classifications of pathogenicity for WDR1-related disorder; criteria provided, conflicting classifications (1 of 4 stars, 5 submitters), last evaluated 2024-11-15.
ClinVar record 1054643 NM_017491.5(WDR1):c.512C>T (p.Ala171Val)
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs182603736 is a single position in the genome, in or near the WDR1 gene. Published research associates it with urate levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Gout. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nature genetics 2021, PMID:33462484. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Urate levels (rs182603736). MyGeneLog™. https://www.mygenelog.com/variants/rs182603736