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Who was studied 394,642 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.155 lower (95% confidence interval 0.11-0.2); p = 9 × 10−12.
How common The A allele had a frequency of about 0% in the people studied.
Where it sits Chromosome 16, band 16q24.1 — between genes, 11.2 kb from IRF8.
What each result means
A/ATwo copies of the version the research linked to Monocyte percentage (UKB data field 30190). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Monocyte percentage (UKB data field 30190). That is a smaller link than two copies.
G/GNo copy of the version the research linked to Monocyte percentage (UKB data field 30190). This is the starting point the study compared everyone against.
Nature genetics · 2025 · PMID 39789286 · open access
Questions about rs182321587
What is rs182321587?
rs182321587 is a single position in the genome, in or near the near IRF8 gene. Published research associates it with monocyte percentage (ukb data field 30190). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs182321587 linked to?
On MyGeneLog this position is linked to Celiac Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs182321587 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs182321587 come from?
GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 422Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others2Total4Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Monocyte percentage (UKB data field 30190) (rs182321587). MyGeneLog™. https://www.mygenelog.com/variants/rs182321587