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Sleep duration

PAX8 · rs1823125

Where this position leads

Condition: Sleep and Circadian Rhythm

rs1823125 Condition: Sleep and Circadian Rhythm Sleep and Circadian Rhythm Condition rs1823125 rs1823125 PAX8

What the study found

Who was studied 47,180 European ancestry individuals; replicated in 4,771 African American individuals.

The effect Each copy of the G allele shifted the measure 3.14 higher; p = 1 × 10−10.

How common The G allele had a frequency of about 26% in the people studied.

Where it sits Chromosome 2, band 2q14.1 — in an intron of LINC02966.

What each result means

A/A No copy of the version the research linked to Sleep duration. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Sleep duration. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Sleep duration. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

What people read about alongside this

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs1823125

What is rs1823125?

rs1823125 is a single position in the genome, in or near the PAX8 gene. Published research associates it with sleep duration. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1823125 linked to?

On MyGeneLog this position is linked to Sleep and Circadian Rhythm. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs1823125?

Subjects that appear in the title or abstract of the same papers as this rsID include adhd and attention (1 papers), sleep and insomnia (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs1823125 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1823125 come from?

GWAS Catalog, Mol Psychiatry 2014, PMID:25469926. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Sleep duration (rs1823125). MyGeneLog™. https://www.mygenelog.com/variants/rs1823125

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