Arthropathy associated with other disorders (PheCode 713)
near METAP2P1 · rs182235317
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Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 406 African American or Afro-Caribbean cases, 121,043 African American or Afro-Caribbean controls, 2,243 European ancestry cases, 447,431 European ancestry controls, 223 Hispanic or Latin American cases, 59,496 Hispanic or Latin American controls.
The effect
Each copy of the G allele shifted the measure 3.04 lower (95% confidence interval 3.01-3.07); p = 1 × 10−12.
How common The G allele had a frequency of about 100% in the people studied.
Where it sits Chromosome 2, band 2q22.3 — between genes, 182.3 kb from METAP2P1.
What each result means
A/APublished research associates this genotype with typical/baseline likelihood of Arthropathy associated with other disorders (PheCode 713) — no copies of the reported risk allele.
A/GPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Arthropathy associated with other disorders (PheCode 713).
G/GPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Arthropathy associated with other disorders (PheCode 713) compared to the general population.
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access
Questions about rs182235317
What is rs182235317?
rs182235317 is a single position in the genome, in or near the near METAP2P1 gene. Published research associates it with arthropathy associated with other disorders (phecode 713). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs182235317 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs182235317 come from?
GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Arthropathy associated with other disorders (PheCode 713) (rs182235317). MyGeneLog™. https://www.mygenelog.com/variants/rs182235317