Standard

TPSAB1 protein levels

near PRSS29P · rs182106504

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 47,745 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.354 lower (95% confidence interval 0.25-0.45); p = 4 × 10⁻¹⁵.

How common The A allele had a frequency of about 0% in the people studied.

Where it sits Chromosome 16, band 16p13.3 — between genes, 10.5 kb from PRSS29P.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of TPSAB1 protein levels compared to the general population.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with TPSAB1 protein levels.

G/G Published research associates this genotype with typical/baseline likelihood of TPSAB1 protein levels — no copies of the reported risk allele.

Source

A scalable variational inference approach for increased mixed-model association power

Loya H, Kalantzis G, Cooper F, Palamara PF

Nature genetics · 2025 · PMID 39789286 · open access

Questions about rs182106504

What is rs182106504?

rs182106504 is a single position in the genome, in or near the near PRSS29P gene. Published research associates it with tpsab1 protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs182106504 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs182106504 come from?

GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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TPSAB1 protein levels (rs182106504). MyGeneLog™. https://www.mygenelog.com/variants/rs182106504

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