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Who was studied 450 African American or Afro-Caribbean cases, 120,910 African American or Afro-Caribbean controls, 903 European ancestry cases, 449,159 European ancestry controls.
The effect
Each copy of the C allele shifted the measure 1.88 lower (95% confidence interval 1.82-1.94); p = 2 × 10−12.
How common The C allele had a frequency of about 100% in the people studied.
Where it sits Chromosome 4, band 4q22.3 — between genes, 103.7 kb from RNU6-1059P.
What each result means
C/CTwo copies of the version the research linked to Folate-deficiency anemia (PheCode 281.13). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/GOne copy of the version the research linked to Folate-deficiency anemia (PheCode 281.13). That is a smaller link than two copies.
G/GNo copy of the version the research linked to Folate-deficiency anemia (PheCode 281.13). This is the starting point the study compared everyone against.
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access
Questions about rs181869483
What is rs181869483?
rs181869483 is a single position in the genome, in or near the near RNU6-1059P gene. Published research associates it with folate-deficiency anemia (phecode 281.13). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs181869483 linked to?
On MyGeneLog this position is linked to Folate-deficiency Anemia. The research behind each link, and its sources, are set out on that condition page.
Does having rs181869483 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs181869483 come from?
GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 5122Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others2Total5Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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