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Who was studied 434,646 British ancestry individuals, 8,796 British Central/South Asian individuals, 6,573 British African individuals.
The effect
Each copy of the C allele shifted the measure 0.01 mmol/L lower (95% confidence interval 0.01-0.01); p = 1 × 10−10.
Where it sits Chromosome 12, band 12q12 — between genes, 14 kb from Y_RNA.
What each result means
A/ANo copy of the version the research linked to Total lipids in large HDL. This is the starting point the study compared everyone against.
A/COne copy of the version the research linked to Total lipids in large HDL. That is a smaller link than two copies.
C/CTwo copies of the version the research linked to Total lipids in large HDL. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2025 · PMID 41044249 · open access
Questions about rs1817649
What is rs1817649?
rs1817649 is a single position in the genome, in or near the near Y_RNA gene. Published research associates it with total lipids in large hdl. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1817649 linked to?
On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.
Does having rs1817649 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1817649 come from?
GWAS Catalog, Nature genetics 2025, PMID:41044249. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 7124Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others4Total7Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Total lipids in large HDL (rs1817649). MyGeneLog™. https://www.mygenelog.com/variants/rs1817649