ZNF295-AS1 · rs181586684
Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 612 African American or Afro-Caribbean cases, 120,665 African American or Afro-Caribbean controls, 710 European ancestry cases, 449,706 European ancestry controls.
The effect Each copy of the C allele shifted the measure 2.75 lower (95% confidence interval 2.72-2.78); p = 1 × 10−12.
How common The C allele had a frequency of about 100% in the people studied.
Where it sits Chromosome 21, band 21q22.3 — in an intron of ZNF295-AS1.
rs181586684 is a single position in the genome, in or near the ZNF295-AS1 gene. Published research associates it with exophthalmos (phecode 242.3). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Exophthalmos (PheCode 242.3) (rs181586684). MyGeneLog™. https://www.mygenelog.com/variants/rs181586684