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Who was studied 394,642 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.199 higher (95% confidence interval 0.14-0.26); p = 1 × 10−12.
How common The A allele had a frequency of about 0% in the people studied.
Where it sits Chromosome 1, band 1q23.2 — between genes, 23.6 kb from CRPP1.
What each result means
A/APublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of C-reactive protein levels (UKB data field 30710) compared to the general population.
A/GPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with C-reactive protein levels (UKB data field 30710).
G/GPublished research associates this genotype with typical/baseline likelihood of C-reactive protein levels (UKB data field 30710) — no copies of the reported risk allele.
Nature genetics · 2025 · PMID 39789286 · open access
Questions about rs180915227
What is rs180915227?
rs180915227 is a single position in the genome, in or near the near CRPP1 gene. Published research associates it with c-reactive protein levels (ukb data field 30710). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs180915227 linked to?
On MyGeneLog this position is linked to C-Reactive Protein Levels. The research behind each link, and its sources, are set out on that condition page.
Does having rs180915227 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs180915227 come from?
GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 2110Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon0Apple0Others0Total2Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
C-reactive protein levels (UKB data field 30710) (rs180915227). MyGeneLog™. https://www.mygenelog.com/variants/rs180915227