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Male-pattern baldness

HOXC12 · rs180807105

Where this position leads

Condition: Androgenetic Alopecia (Male Pattern Baldness)

rs180807105 Condition: Androgenetic Alopecia (Male Pattern Baldness) Androgenetic Alopecia (Male Pattern… Condition rs180807105 rs180807105 HOXC12

What the study found

Who was studied 205,327 European ancestry males.

The effect Each copy of the G allele shifted the measure 0.183 lower (95% confidence interval 0.15-0.22); p = 2 × 10−22.

How common The G allele had a frequency of about 1% in the people studied.

Where it sits Chromosome 12, band 12q13.13 — in an intron of HOXC12.

What each result means

A/A No copy of the version the research linked to Male-pattern baldness. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Male-pattern baldness. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Male-pattern baldness. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs180807105

What is rs180807105?

rs180807105 is a single position in the genome, in or near the HOXC12 gene. Published research associates it with male-pattern baldness. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs180807105 linked to?

On MyGeneLog this position is linked to Androgenetic Alopecia (Male Pattern Baldness). The research behind each link, and its sources, are set out on that condition page.

Does having rs180807105 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs180807105 come from?

GWAS Catalog, Nat Commun 2018, PMID:30573740. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Male-pattern baldness (rs180807105). MyGeneLog™. https://www.mygenelog.com/variants/rs180807105

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