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Who was studied 7,551 European ancestry cases, 1,258,581 European ancestry controls.
The effect
Each copy of the G allele shifted the measure 1.4 higher (95% confidence interval 1.34-1.46); p = 1 × 10−300.
How common The G allele had a frequency of about 2% in the people studied.
Where it sits Chromosome 6, band 6p22.1 — between genes, 3.2 kb from LINC00533.
What each result means
A/ANo copy of the version the research linked to Ankylosing spondylitis. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Ankylosing spondylitis. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Ankylosing spondylitis. That is the strongest link of the three results. A link in a study is not a diagnosis.
Frontiers in immunology · 2026 · PMID 42305533 · open access
Questions about rs180679588
What is rs180679588?
rs180679588 is a single position in the genome, in or near the near LINC00533 gene. Published research associates it with ankylosing spondylitis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs180679588 linked to?
On MyGeneLog this position is linked to Ankylosing Spondylitis. The research behind each link, and its sources, are set out on that condition page.
Does having rs180679588 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs180679588 come from?
GWAS Catalog, Frontiers in immunology 2026, PMID:42305533. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 624Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others4Total6Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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