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Who was studied 20,065 European ancestry cases, 33,065 European ancestry controls, 1,045 other-admixed ancestry cases, 1,103 other-admixed ancestry controls, 1,043 African ancestry cases, 3,206 African ancestry controls.
The effect
Each copy of the C allele carried 1.07 times the odds of Type 1 diabetes; p = 4 × 10−8.
How common The C allele had a frequency of about 39% in the people studied.
Where it sits Chromosome 12, band 12p13.31 — in the 3′ untranslated region of M6PR.
What each result means
C/CTwo copies of the version the research linked to Type 1 diabetes. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Type 1 diabetes. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Type 1 diabetes. This is the starting point the study compared everyone against.
Nature genetics · 2021 · PMID 34127860 · open access
Questions about rs1805731
What is rs1805731?
rs1805731 is a single position in the genome, in or near the M6PR gene. Published research associates it with type 1 diabetes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1805731 linked to?
On MyGeneLog this position is linked to Type 1 Diabetes. The research behind each link, and its sources, are set out on that condition page.
Does having rs1805731 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1805731 come from?
GWAS Catalog, Nat Genet 2021, PMID:34127860. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Type 1 diabetes (rs1805731). MyGeneLog™. https://www.mygenelog.com/variants/rs1805731