KCNH2 · rs1805120
Where this position leads
Condition: QT Interval and Drug-Induced Long QT
What the study found
Who was studied 27,612 European ancestry women.
The effect Each copy of the G allele shifted the measure 0.081 lower (95% confidence interval 0.067-0.095); p = 6 × 10−30.
How common The G allele had a frequency of about 79% in the people studied.
Where it sits Chromosome 7, band 7q36.1 — a synonymous change in KCNH2.
What ClinVar records
Classification
Benign/Likely benign for Long QT syndrome, Cardiovascular phenotype, Long QT syndrome 2, Cardiac arrhythmia; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 17 submitters), last evaluated 2026-02-04.
ClinVar record 36428 NM_000238.4(KCNH2):c.1539C>T (p.Phe513=)
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs1805120 is a single position in the genome, in or near the KCNH2 gene. Published research associates it with qt interval. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to QT Interval and Drug-Induced Long QT. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Human molecular genetics 2021, PMID:34274964. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
QT interval (rs1805120). MyGeneLog™. https://www.mygenelog.com/variants/rs1805120