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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 321,047 European ancestry individuals; replicated in 79,005 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.0844 lower (95% confidence interval 0.065-0.104); p = 6 × 10−18.
How common The T allele had a frequency of about 1% in the people studied.
Where it sits Chromosome 5, band 5q32 — a missense change in ADRB2.
What ClinVar records
ClassificationBenign for Beta-2-adrenoreceptor agonist, reduced response to; criteria provided, single submitter (1 of 4 stars, 2 submitters), last evaluated 2022-11-01.
ClinVar record 17744NM_000024.6(ADRB2):c.491C>T (p.Thr164Ile)
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
C/CPublished research associates this genotype with typical/baseline likelihood of FEV1 — no copies of the reported risk allele.
C/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with FEV1.
T/TPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of FEV1 compared to the general population.
Nature genetics · 2019 · PMID 30804560 · open access
Questions about rs1800888
What is rs1800888?
rs1800888 is a single position in the genome, in or near the ADRB2 gene. Published research associates it with fev1. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs1800888 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1800888 come from?
GWAS Catalog, Nature genetics 2019, PMID:30804560. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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