Sensitive

Erosive hand osteoarthritis

MGP · rs1800801

Where this position leads

What the study found

Who was studied 1,484 European ancestry cases, 550,680 European ancestry controls.

The effect Each copy of the T allele carried 1.37 times the odds of Erosive hand osteoarthritis (95% confidence interval 1.26-1.49); p = 4 × 10⁻¹³.

How common The T allele had a frequency of about 37% in the people studied.

Where it sits Chromosome 12, band 12p12.3 — in the 5′ untranslated region of MGP.

What ClinVar records

Classification Benign for Keutel syndrome; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 4 submitters), last evaluated 2025-10-27. ClinVar record 307776 NM_000900.5(MGP):c.-63G>A

What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

C/C No copy of the version the research linked to Erosive hand osteoarthritis. This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to Erosive hand osteoarthritis. That is a smaller link than two copies.

T/T Two copies of the version the research linked to Erosive hand osteoarthritis. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Meta-analysis of erosive hand osteoarthritis identifies four common variants that associate with relatively large effect

Styrkarsdottir U, Stefansdottir L, Thorleifsson G, Stefansson OA, Saevarsdottir S, Lund SH, Rafnar T, Hoshijima K, Novak K, Oreiro N, Rego-Perez I, Hansen C

and 10 more — show all

Kazmers N, Kiemeney LA, Blanco FJ, Barker T, Kloppenburg M, Jurynec MJ, Gudbjartsson DF, Jonsson H, Thorsteinsdottir U, Stefansson K

Annals of the rheumatic diseases · 2023 · PMID 36931692 · open access

Questions about rs1800801

What is rs1800801?

rs1800801 is a single position in the genome, in or near the MGP gene. Published research associates it with erosive hand osteoarthritis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1800801 linked to?

On MyGeneLog this position is linked to Osteoarthritis. The research behind each link, and its sources, are set out on that condition page.

Does having rs1800801 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1800801 come from?

GWAS Catalog, Annals of the rheumatic diseases 2023, PMID:36931692. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Erosive hand osteoarthritis (rs1800801). MyGeneLog™. https://www.mygenelog.com/variants/rs1800801

← See all variants