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Clonal hematopoiesis (mutational barcode method)

near HLA-C · rs1793890

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10−8, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 59,219 British, Irish ancestry individuals.

The effect Each copy of the A allele carried 0.92 times the odds of Clonal hematopoiesis (mutational barcode method) (95% confidence interval 0.9-0.95); p = 6 × 10−9.

Where it sits Chromosome 6, band 6p21.33 — between genes, 14.5 kb from HLA-C.

What each result means

A/A Two copies of the version the research linked to Clonal hematopoiesis (mutational barcode method). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Clonal hematopoiesis (mutational barcode method). That is a smaller link than two copies.
G/G No copy of the version the research linked to Clonal hematopoiesis (mutational barcode method). This is the starting point the study compared everyone against.
Source
Genetics and epidemiology of mutational barcode-defined clonal hematopoiesis
Stacey SN, Zink F, Halldorsson GH, Stefansdottir L, Gudjonsson SA, Einarsson G, Hjörleifsson G, Eiriksdottir T, Helgadottir A, Björnsdottir G, Thorgeirsson TE, Olafsdottir TA
and 19 more — show all
Jonsdottir I, Gretarsdottir S, Tragante V, Magnusson MK, Jonsson H, Gudmundsson J, Olafsson S, Holm H, Gudbjartsson DF, Sulem P, Helgason A, Thorsteinsdottir U, Tryggvadottir L, Rafnar T, Melsted P, Ulfarsson MÖ, Vidarsson B, Thorleifsson G, Stefansson K
Nature genetics · 2023 · PMID 37932435 · open access

Questions about rs1793890

What is rs1793890?

rs1793890 is a single position in the genome, in or near the near HLA-C gene. Published research associates it with clonal hematopoiesis (mutational barcode method). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs1793890 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1793890 come from?

GWAS Catalog, Nature genetics 2023, PMID:37932435. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Clonal hematopoiesis (mutational barcode method) (rs1793890). MyGeneLog™. https://www.mygenelog.com/variants/rs1793890

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