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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 3,506 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.296 higher (95% confidence interval 0.25-0.34); p = 2 × 10−36.
How common The T allele had a frequency of about 29% in the people studied.
Where it sits Chromosome 18, band 18q12.1 — in an intron of DSC2.
What ClinVar records
ClassificationBenign for Hepatocellular carcinoma; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 3 submitters), last evaluated 2018-06-14.
ClinVar record 672107NM_024422.6(DSC2):c.355-102A>C
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
G/GNo copy of the version the research linked to Desmocollin-2 levels. This is the starting point the study compared everyone against.
G/TOne copy of the version the research linked to Desmocollin-2 levels. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Desmocollin-2 levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs1790683 is a single position in the genome, in or near the DSC2 gene. Published research associates it with desmocollin-2 levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs1790683 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1790683 come from?
GWAS Catalog, Nature genetics 2024, PMID:39528825. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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