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Who was studied 58,783 European ancestry cases, 633,203 European ancestry controls.
The effect
Each copy of the A allele carried 1.05 times the odds of Hypothyroidism (95% confidence interval 1.04-1.07); p = 4 × 10−11.
Where it sits Chromosome 18, band 18q22.2 — inside CD226.
What each result means
A/APublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Hypothyroidism compared to the general population.
A/GPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Hypothyroidism.
G/GPublished research associates this genotype with typical/baseline likelihood of Hypothyroidism — no copies of the reported risk allele.
European journal of endocrinology · 2024 · PMID 39067062
Questions about rs1790604
What is rs1790604?
rs1790604 is a single position in the genome, in or near the CD226 gene. Published research associates it with hypothyroidism. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1790604 linked to?
On MyGeneLog this position is linked to Hypothyroidism. The research behind each link, and its sources, are set out on that condition page.
Does having rs1790604 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1790604 come from?
GWAS Catalog, European journal of endocrinology 2024, PMID:39067062. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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