Standard

Alcohol consumption (drinks per week) (MTAG)

near PPARA · rs17884691

Where this position leads

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Alcohol consumption (drinks per week) (MTAG) compared to the general population.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Alcohol consumption (drinks per week) (MTAG).

G/G Published research associates this genotype with typical/baseline likelihood of Alcohol consumption (drinks per week) (MTAG) — no copies of the reported risk allele.

Source

Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits

Zhou H, Sealock JM, Sanchez-Roige S, Clarke TK, Levey DF, Cheng Z, Li B, Polimanti R, Kember RL, Smith RV, Thygesen JH, Morgan MY

and 15 more — show all

Atkinson SR, Thursz MR, Nyegaard M, Nyegaard M, Mattheisen M, Børglum AD, Johnson EC, Justice AC, Palmer AA, McQuillin A, Davis LK, Edenberg HJ, Agrawal A, Kranzler HR, Gelernter J

Nature neuroscience · 2020 · PMID 32451486 · open access

Questions about rs17884691

What is rs17884691?

rs17884691 is a single position in the genome, in or near the near PPARA gene. Published research associates it with alcohol consumption (drinks per week) (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs17884691 linked to?

On MyGeneLog this position is linked to Alcohol Consumption. The research behind each link, and its sources, are set out on that condition page.

Does having rs17884691 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs17884691 come from?

GWAS Catalog, Nature neuroscience 2020, PMID:32451486. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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