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Cancer of bladder (PheCode 189.2)

near UGT1A11P · rs17868304

Where this position leads

Condition: Bladder Cancer

rs17868304 Condition: Bladder Cancer Bladder Cancer Condition rs17868304 rs17868304 near UGT1A11P

What the study found

Who was studied 1,271 African American or Afro-Caribbean cases, 119,876 African American or Afro-Caribbean controls, 11,744 European ancestry cases, 436,406 European ancestry controls, 644 Hispanic or Latin American cases, 58,949 Hispanic or Latin American controls.

The effect Each copy of the C allele shifted the measure 0.406 higher (95% confidence interval 0.27-0.55); p = 4 × 10−16.

How common The C allele had a frequency of about 97% in the people studied.

Where it sits Chromosome 2, band 2q37.1 — between genes, 4.3 kb from UGT1A11P.

What each result means

C/C Two copies of the version the research linked to Cancer of bladder (PheCode 189.2). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Cancer of bladder (PheCode 189.2). That is a smaller link than two copies.
T/T No copy of the version the research linked to Cancer of bladder (PheCode 189.2). This is the starting point the study compared everyone against.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs17868304

What is rs17868304?

rs17868304 is a single position in the genome, in or near the near UGT1A11P gene. Published research associates it with cancer of bladder (phecode 189.2). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs17868304 linked to?

On MyGeneLog this position is linked to Bladder Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs17868304 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs17868304 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Cancer of bladder (PheCode 189.2) (rs17868304). MyGeneLog™. https://www.mygenelog.com/variants/rs17868304

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