Sensitive

Bladder cancer

UGT1A8 · rs17863783

Where this position leads

What the study found

Who was studied 13,447 European ancestry cases, 342,580 European ancestry controls.

The effect Each copy of the G allele carried 1.75 times the odds of Bladder cancer (95% confidence interval 1.55-1.98); p = 9 × 10⁻²⁰.

How common The G allele had a frequency of about 98% in the people studied.

Where it sits Chromosome 2, band 2q37.1 — a synonymous change in UGT1A8.

What ClinVar records

Classification Benign; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 2 submitters), last evaluated 2025-07-01. ClinVar record 440382 NM_001072.4(UGT1A6):c.627G>T (p.Val209=)

What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

G/G Two copies of the version the research linked to Bladder cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.

G/T One copy of the version the research linked to Bladder cancer. That is a smaller link than two copies.

T/T No copy of the version the research linked to Bladder cancer. This is the starting point the study compared everyone against.

Source

Genome-wide Association Study of Bladder Cancer Reveals New Biological and Translational Insights

Koutros S, Kiemeney LA, Pal Choudhury P, Milne RL, Lopez de Maturana E, Ye Y, Joseph V, Florez-Vargas O, Dyrskjøt L, Figueroa J, Dutta D, Giles GG

and 88 more — show all

Hildebrandt MAT, Offit K, Kogevinas M, Weiderpass E, McCullough ML, Freedman ND, Albanes D, Kooperberg C, Cortessis VK, Karagas MR, Johnson A, Schwenn MR, Baris D, Furberg H, Bajorin DF, Cussenot O, Cancel-Tassin G, Benhamou S, Kraft P, Porru S, Carta A, Bishop T, Southey MC, Matullo G, Fletcher T, Kumar R, Taylor JA, Lamy P, Prip F, Kalisz M, Weinstein SJ, Hengstler JG, Selinski S, Harland M, Teo M, Kiltie AE, Tardón A, Serra C, Carrato A, García-Closas R, Lloreta J, Schned A, Lenz P, Riboli E, Brennan P, Tjønneland A, Otto T, Ovsiannikov D, Volkert F, Vermeulen SH, Aben KK, Galesloot TE, Turman C, De Vivo I, Giovannucci E, Hunter DJ, Hohensee C, Hunt R, Patel AV, Huang WY, Thorleifsson G, Gago-Dominguez M, Amiano P, Golka K, Stern MC, Yan W, Liu J, Li SA, Katta S, Hutchinson A, Hicks B, Wheeler WA, Purdue MP, McGlynn KA, Kitahara CM, Haiman CA, Greene MH, Rafnar T, Chatterjee N, Chanock SJ, Wu X, Real FX, Silverman DT, Garcia-Closas M, Stefansson K, Prokunina-Olsson L, Malats N, Rothman N

UROMOL Consortium

European urology · 2023 · PMID 37210288

Questions about rs17863783

What is rs17863783?

rs17863783 is a single position in the genome, in or near the UGT1A8 gene. Published research associates it with bladder cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs17863783 linked to?

On MyGeneLog this position is linked to Bladder Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs17863783 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs17863783 come from?

GWAS Catalog, European urology 2023, PMID:37210288. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Bladder cancer (rs17863783). MyGeneLog™. https://www.mygenelog.com/variants/rs17863783

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