0 44325212227Reads by AI crawlersClaude3ChatGPT2Google · Gemini0Perplexity0Meta AI5Microsoft · Copilot2Amazon1Apple2China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others27Total44Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 59,674 European ancestry cases, 316,078 European ancestry controls.
The effect
Each copy of the C allele carried 1.06 times the odds of Migraine (95% confidence interval 1.04-1.08); p = 5 × 10−10.
How common The C allele had a frequency of about 17% in the people studied.
Where it sits Chromosome 17, band 17q25.3 — a missense change in RNF213.
What ClinVar records
ClassificationBenign for RNF213-related disorder; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 4 submitters), last evaluated 2026-01-28.
ClinVar record 1601109NM_001256071.3(RNF213):c.809T>C (p.Met270Thr)
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
C/CTwo copies of the version the research linked to Migraine. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Migraine. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Migraine. This is the starting point the study compared everyone against.
rs17857135 is a single position in the genome, in or near the RNF213 gene. Published research associates it with migraine. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs17857135 linked to?
On MyGeneLog this position is linked to Migraine. The research behind each link, and its sources, are set out on that condition page.
Does having rs17857135 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs17857135 come from?
GWAS Catalog, Nat Genet 2016, PMID:27322543. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 44325212227Reads by AI crawlersClaude3ChatGPT2Google · Gemini0Perplexity0Meta AI5Microsoft · Copilot2Amazon1Apple2China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others27Total44Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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