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Who was studied 84,492 European ancestry cases, 2,149 African American cases, 606 Hispanic cases, 1,239 Japanese ancestry cases, 437,036 European ancestry controls, 6,055 African American controls, 792 Hispanic controls, 3,976 Japanese ancestry controls.
The effect
The reported allele is T; the catalogue records no effect size
; p = 2 × 10−9.
How common The T allele had a frequency of about 70% in the people studied.
Where it sits Chromosome 11, band 11q23.1 — between genes, 0.7 kb from SIK2.
What each result means
C/CNo copy of the version the research linked to Asthma. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Asthma. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Asthma. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2020 · PMID 32296059 · open access
Questions about rs1784776
What is rs1784776?
rs1784776 is a single position in the genome, in or near the SIK2 gene. Published research associates it with asthma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1784776 linked to?
On MyGeneLog this position is linked to Asthma. The research behind each link, and its sources, are set out on that condition page.
Does having rs1784776 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1784776 come from?
GWAS Catalog, Nature communications 2020, PMID:32296059. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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