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Its strongest genetic-study result is p = 10−22, with 17 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 408,112 British individuals.
The effect
Each copy of the T allele shifted the measure 0.0508 lower (95% confidence interval 0.041-0.061); p = 9 × 10−23.
How common The T allele had a frequency of about 5% in the people studied.
Where it sits Chromosome 17, band 17q22 — in an intron of MSI2.
What each result means
C/CNo copy of the version the research linked to Eosinophil count. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Eosinophil count. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Eosinophil count. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs17834140 is a single position in the genome, in or near the MSI2 gene. Published research associates it with eosinophil count. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs17834140 linked to?
On MyGeneLog this position is linked to Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.
Does having rs17834140 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs17834140 come from?
GWAS Catalog, Cell 2020, PMID:32888494. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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