Standard

Membranous nephropathy

PLA2R1 · rs17831251

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 2,150 European ancestry cases, 5,829 European ancestry controls, 1,612 East Asian ancestry cases, 1,970 East Asian ancestry controls; replicated in 826 Chinese ancestry cases, 1,239 Chinese ancestry controls.

The effect Each copy of the C allele carried 2.25 times the odds of Membranous nephropathy (95% confidence interval 2.09-2.42); p = 5 × 10⁻¹⁰³.

Where it sits Chromosome 2, band 2q24.2 — in an intron of PLA2R1.

What each result means

C/C Two copies of the version the research linked to Membranous nephropathy. That is the strongest link of the three results. A link in a study is not a diagnosis.

C/T One copy of the version the research linked to Membranous nephropathy. That is a smaller link than two copies.

T/T No copy of the version the research linked to Membranous nephropathy. This is the starting point the study compared everyone against.

Source

The genetic architecture of membranous nephropathy and its potential to improve non-invasive diagnosis

Xie J, Liu L, Mladkova N, Li Y, Ren H, Wang W, Cui Z, Lin L, Hu X, Yu X, Xu J, Liu G

and 108 more — show all

Caliskan Y, Sidore C, Balderes O, Rosen RJ, Bodria M, Zanoni F, Zhang JY, Krithivasan P, Mehl K, Marasa M, Khan A, Ozay F, Canetta PA, Bomback AS, Appel GB, Sanna-Cherchi S, Sampson MG, Mariani LH, Perkowska-Ptasinska A, Durlik M, Mucha K, Moszczuk B, Foroncewicz B, Pączek L, Habura I, Ars E, Ballarin J, Mani LY, Vogt B, Ozturk S, Yildiz A, Seyahi N, Arikan H, Koc M, Basturk T, Karahan G, Akgul SU, Sever MS, Zhang D, Santoro D, Bonomini M, Londrino F, Gesualdo L, Reiterova J, Tesar V, Izzi C, Savoldi S, Spotti D, Marcantoni C, Messa P, Galliani M, Roccatello D, Granata S, Zaza G, Lugani F, Ghiggeri G, Pisani I, Allegri L, Sprangers B, Park JH, Cho B, Kim YS, Kim DK, Suzuki H, Amoroso A, Cattran DC, Fervenza FC, Pani A, Hamilton P, Harris S, Gupta S, Cheshire C, Dufek S, Issler N, Pepper RJ, Connolly J, Powis S, Bockenhauer D, Stanescu HC, Ashman N, Loos RJF, Kenny EE, Wuttke M, Eckardt KU, Köttgen A, Hofstra JM, Coenen MJH, Kiemeney LA, Akilesh S, Kretzler M, Beck LH, Stengel B, Debiec H, Ronco P, Wetzels JFM, Zoledziewska M, Cucca F, Ionita-Laza I, Lee H, Hoxha E, Stahl RAK, Brenchley P, Scolari F, Zhao MH, Gharavi AG, Kleta R, Chen N, Kiryluk K

Nature communications · 2020 · PMID 32231244 · open access

Questions about rs17831251

What is rs17831251?

rs17831251 is a single position in the genome, in or near the PLA2R1 gene. Published research associates it with membranous nephropathy. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs17831251 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs17831251 come from?

GWAS Catalog, Nature communications 2020, PMID:32231244. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Membranous nephropathy (rs17831251). MyGeneLog™. https://www.mygenelog.com/variants/rs17831251

← See all variants