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Who was studied 28,106 European, African, Admixed American, East Asian, South Asian or unknown ancestry individuals (MTAG effective sample size boosted by left ventricular trait samples).
The effect
Each copy of the T allele shifted the measure 0.164 higher (95% confidence interval 0.12-0.21); p = 6 × 10−13.
How common The T allele had a frequency of about 26% in the people studied.
Where it sits Chromosome 17, band 17q22 — in an intron of HLF.
What each result means
C/CNo copy of the version the research linked to Hypertrophic cardiomyopathy (MTAG). This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Hypertrophic cardiomyopathy (MTAG). That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Hypertrophic cardiomyopathy (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2025 · PMID 39966646 · open access
Questions about rs17817857
What is rs17817857?
rs17817857 is a single position in the genome, in or near the HLF gene. Published research associates it with hypertrophic cardiomyopathy (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs17817857 linked to?
On MyGeneLog this position is linked to Hypertrophic Cardiomyopathy. The research behind each link, and its sources, are set out on that condition page.
Does having rs17817857 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs17817857 come from?
GWAS Catalog, Nature genetics 2025, PMID:39966646. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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