Standard

Mean volume of bilateral amygdala

near IGF1 · rs17797222

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 35,474 European ancestry individuals, 6,923 East Asian ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.0517 lower (95% confidence interval 0.04-0.063); p = 6 × 10⁻¹⁸.

Where it sits Chromosome 12, band 12q23.2 — between genes, 38.4 kb from IGF1.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Mean volume of bilateral amygdala — no copies of the reported risk allele.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Mean volume of bilateral amygdala.

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Mean volume of bilateral amygdala compared to the general population.

Source

Cross-ancestry and sex-stratified genome-wide association analyses of amygdala and subnucleus volumes

Ji Y, Liu N, Yang Y, Wang M, Cheng J, Zhu W, Qiu S, Geng Z, Cui G, Yu Y, Liao W, Zhang H

and 33 more — show all

Gao B, Xu X, Han T, Yao Z, Zhang Q, Qin W, Liu F, Liang M, Wang S, Xu Q, Xu J, Fu J, Zhang P, Li W, Shi D, Wang C, Lui S, Yan Z, Chen F, Zhang J, Shen W, Miao Y, Wang D, Gao JH, Zhang X, Xu K, Zuo XN, Zhang L, Ye Z, Li MJ, Xian J, Zhang B, Yu C

CHIMGEN Consortium

Nature genetics · 2025 · PMID 40097784

Questions about rs17797222

What is rs17797222?

rs17797222 is a single position in the genome, in or near the near IGF1 gene. Published research associates it with mean volume of bilateral amygdala. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs17797222 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs17797222 come from?

GWAS Catalog, Nature genetics 2025, PMID:40097784. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Mean volume of bilateral amygdala (rs17797222). MyGeneLog™. https://www.mygenelog.com/variants/rs17797222

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