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Major depressive disorder (PheCode 296.22)

LRFN5-DT · rs17781288

Where this position leads

Condition: Major Depressive Disorder

rs17781288 Condition: Major Depressive Disorder Major Depressive Disorder Condition rs17781288 rs17781288 LRFN5-DT

What the study found

Who was studied 50,152 African American or Afro-Caribbean cases, 62,945 African American or Afro-Caribbean controls, 24,050 Hispanic or Latin American cases, 31,470 Hispanic or Latin American controls, 2,053 East Asian ancestry cases, 4,384 East Asian ancestry controls, 139,131 European ancestry cases, 284,850 European ancestry controls.

The effect Each copy of the C allele shifted the measure 0.035 higher (95% confidence interval 0.025-0.044); p = 1 × 10−13.

How common The C allele had a frequency of about 58% in the people studied.

Where it sits Chromosome 14, band 14q21.1 — in an intron of LRFN5-DT.

What each result means

C/C Two copies of the version the research linked to Major depressive disorder (PheCode 296.22). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/G One copy of the version the research linked to Major depressive disorder (PheCode 296.22). That is a smaller link than two copies.
G/G No copy of the version the research linked to Major depressive disorder (PheCode 296.22). This is the starting point the study compared everyone against.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs17781288

What is rs17781288?

rs17781288 is a single position in the genome, in or near the LRFN5-DT gene. Published research associates it with major depressive disorder (phecode 296.22). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs17781288 linked to?

On MyGeneLog this position is linked to Major Depressive Disorder. The research behind each link, and its sources, are set out on that condition page.

Does having rs17781288 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs17781288 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Major depressive disorder (PheCode 296.22) (rs17781288). MyGeneLog™. https://www.mygenelog.com/variants/rs17781288

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