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Who was studied 56,355 European ancestry cases, 398,413 European ancestry controls.
The effect
Each copy of the G allele shifted the measure 0.04 higher (95% confidence interval 0.03-0.05); p = 1 × 10−10.
How common The G allele had a frequency of about 56% in the people studied.
Where it sits Chromosome 4, band 4p16.1 — in an intron of AFAP1.
What each result means
A/ANo copy of the version the research linked to Diverticular disease. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Diverticular disease. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Diverticular disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
Cell genomics · 2023 · PMID 37492107 · open access
Questions about rs17770321
What is rs17770321?
rs17770321 is a single position in the genome, in or near the AFAP1 gene. Published research associates it with diverticular disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs17770321 linked to?
On MyGeneLog this position is linked to Diverticular Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs17770321 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs17770321 come from?
GWAS Catalog, Cell genomics 2023, PMID:37492107. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 11Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others1Total1Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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