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Its strongest genetic-study result is p = 10−7, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 100,671 European ancestry cases, 2,106,212 European ancestry controls.
The effect
Each copy of the A allele carried 1.03 times the odds of Gout (95% confidence interval 1.02-1.04); p = 4 × 10−8.
How common The A allele had a frequency of about 30% in the people studied.
Where it sits Chromosome 18, band 18q12.3 — between genes, 11.1 kb from SLC14A2.
What each result means
A/ATwo copies of the version the research linked to Gout. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/COne copy of the version the research linked to Gout. That is a smaller link than two copies.
C/CNo copy of the version the research linked to Gout. This is the starting point the study compared everyone against.
rs17740231 is a single position in the genome, in or near the near SLC14A2 gene. Published research associates it with gout. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs17740231 linked to?
On MyGeneLog this position is linked to Gout. The research behind each link, and its sources, are set out on that condition page.
Does having rs17740231 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs17740231 come from?
GWAS Catalog, Nature genetics 2024, PMID:39406924. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 413Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot1Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others3Total4Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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