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Who was studied 39,717 East Asian ancestry individuals; replicated in 17,461 East Asian ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.0051 mg/dl higher (95% confidence interval 0.0035-0.0067); p = 3 × 10−11.
How common The G allele had a frequency of about 58% in the people studied.
Where it sits Chromosome 15, band 15q21.3 — a missense change in WDR72.
What ClinVar records
ClassificationBenign/Likely benign for Amelogenesis imperfecta hypomaturation type 2A3; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 6 submitters), last evaluated 2024-11-27.
ClinVar record 262999NM_182758.4(WDR72):c.2455C>T (p.Leu819Phe)
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
A/ANo copy of the version the research linked to Renal function-related traits (BUN). This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Renal function-related traits (BUN). That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Renal function-related traits (BUN). That is the strongest link of the three results. A link in a study is not a diagnosis.
rs17730281 is a single position in the genome, in or near the WDR72 gene. Published research associates it with renal function-related traits (bun). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs17730281 linked to?
On MyGeneLog this position is linked to Kidney Function. The research behind each link, and its sources, are set out on that condition page.
Does having rs17730281 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs17730281 come from?
GWAS Catalog, Nat Genet 2012, PMID:22797727. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 4724143222126Reads by AI crawlersClaude2ChatGPT4Google · Gemini1Perplexity4Meta AI3Microsoft · Copilot2Amazon2Apple2China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others26Total47Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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