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Who was studied 1,359 European ancestry cases, 1,400 European ancestry controls; replicated in 5,048 European ancestry cases, 5,041 European ancestry controls.
The effect
Each copy of the A allele carried 1.59 times the odds of Psoriasis; p = 1 × 10−20.
How common The A allele had a frequency of about 5% in the people studied.
Where it sits Chromosome 5, band 5q33.1 — between genes, 1.9 kb from ANXA6.
What each result means
A/ATwo copies of the version the research linked to Psoriasis. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Psoriasis. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Psoriasis. This is the starting point the study compared everyone against.
Nature genetics · 2009 · PMID 19169254 · open access
Questions about rs17728338
What is rs17728338?
rs17728338 is a single position in the genome, in or near the TNIP1 gene. Published research associates it with psoriasis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs17728338 linked to?
On MyGeneLog this position is linked to Psoriasis. The research behind each link, and its sources, are set out on that condition page.
Does having rs17728338 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs17728338 come from?
GWAS Catalog, Nat Genet 2009, PMID:19169254. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 3932115213120Reads by AI crawlersClaude3ChatGPT2Google · Gemini1Perplexity1Meta AI5Microsoft · Copilot2Amazon1Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others20Total39Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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