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COVID-19 (critical illness vs population)

near LZTFL1 · rs17713054

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 682 African ancestry cases, 2,540 African ancestry controls, 401 East Asian ancestry cases, 759 East Asian ancestry controls, 13,199 European ancestry cases, 745,011 European ancestry controls, 1,141 South Asian ancestry cases, 5,384 South Asian ancestry controls, 8,779 cases, 1,001,875 controls.

The effect Each copy of the A allele carried 2.00 times the odds of COVID-19 (critical illness vs population) (95% confidence interval 1.96-2.13); p = 8 × 10−254.

How common The A allele had a frequency of about 10% in the people studied.

Where it sits Chromosome 3, band 3p21.31 — between genes, 5.2 kb from LZTFL1.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of COVID-19 (critical illness vs population) compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with COVID-19 (critical illness vs population).
G/G Published research associates this genotype with typical/baseline likelihood of COVID-19 (critical illness vs population) — no copies of the reported risk allele.
Source
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19
Pairo-Castineira E, Rawlik K, Bretherick AD, Qi T, Wu Y, Nassiri I, McConkey GA, Zechner M, Klaric L, Griffiths F, Oosthuyzen W, Kousathanas A
and 43 more — show all
Richmond A, Millar J, Russell CD, Malinauskas T, Thwaites R, Morrice K, Keating S, Maslove D, Nichol A, Semple MG, Knight J, Shankar-Hari M, Summers C, Hinds C, Horby P, Ling L, McAuley D, Montgomery H, Openshaw PJM, Begg C, Walsh T, Tenesa A, Flores C, Riancho JA, Rojas-Martinez A, Lapunzina P, Yang J, Ponting CP, Wilson JF, Vitart V, Abedalthagafi M, Luchessi AD, Parra EJ, Cruz R, Carracedo A, Fawkes A, Murphy L, Rowan K, Pereira AC, Law A, Fairfax B, Hendry SC, Baillie JK
GenOMICC Investigators · SCOURGE Consortium · ISARICC Investigators · 23andMe COVID-19 Team
Nature · 2023 · PMID 37198478 · open access

Questions about rs17713054

What is rs17713054?

rs17713054 is a single position in the genome, in or near the near LZTFL1 gene. Published research associates it with covid-19 (critical illness vs population). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs17713054 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs17713054 come from?

GWAS Catalog, Nature 2023, PMID:37198478. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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COVID-19 (critical illness vs population) (rs17713054). MyGeneLog™. https://www.mygenelog.com/variants/rs17713054

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