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Sensitive

Pancreatic cancer

SUGCT · rs17688601

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10−8, with 2 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 7,638 cases, 7,364 controls; replicated in 2,287 cases, 4,205 controls.

The effect Each copy of the C allele carried 1.14 times the odds of Pancreatic cancer (95% confidence interval 1.09-1.19); p = 1 × 10−8.

How common The C allele had a frequency of about 74% in the people studied.

Where it sits Chromosome 7, band 7p14.1 — in an intron of SUGCT.

How common each version is

AC
Korean KRGDB
A 2.0% · C 98.0%
Korean Korea4K
A 2.1% · C 97.9%
Korean Korea1K
A 2.1% · C 97.9%
Japanese ToMMo
A 3.2% · C 96.8%
World gnomAD
A 20.0% · C 80.0%
World 1000 Genomes
A 16.7% · C 83.3%
World TOPMed
A 18.7% · C 81.3%

By ancestry gnomAD

East Asian
A 4.4% · C 95.5%
European (non-Finnish)
A 26.4% · C 73.6%
African / African American
A 6.5% · C 93.5%
South Asian
A 34.6% · C 65.4%
Admixed American (Latino)
A 21.8% · C 78.2%
Middle Eastern
A 30.3% · C 69.7%
Finnish
A 27.4% · C 72.7%
Ashkenazi Jewish
A 26.9% · C 73.1%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study. The ancestry rows are gnomAD's own groups (via Ensembl), as the survey defines them, not races.

What each result means

A/A No copy of the version the research linked to Pancreatic cancer. This is the starting point the study compared everyone against.
A/C One copy of the version the research linked to Pancreatic cancer. That is a smaller link than two copies.
C/C Two copies of the version the research linked to Pancreatic cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer
Childs EJ, Mocci E, Campa D, Bracci PM, Gallinger S, Goggins M, Li D, Neale RE, Olson SH, Scelo G, Amundadottir LT, Bamlet WR
and 50 more — show all
Bijlsma MF, Blackford A, Borges M, Brennan P, Brenner H, Bueno-de-Mesquita HB, Canzian F, Capurso G, Cavestro GM, Chaffee KG, Chanock SJ, Cleary SP, Cotterchio M, Foretova L, Fuchs C, Funel N, Gazouli M, Hassan M, Herman JM, Holcatova I, Holly EA, Hoover RN, Hung RJ, Janout V, Key TJ, Kupcinskas J, Kurtz RC, Landi S, Lu L, Malecka-Panas E, Mambrini A, Mohelnikova-Duchonova B, Neoptolemos JP, Oberg AL, Orlow I, Pasquali C, Pezzilli R, Rizzato C, Saldia A, Scarpa A, Stolzenberg-Solomon RZ, Strobel O, Tavano F, Vashist YK, Vodicka P, Wolpin BM, Yu H, Petersen GM, Risch HA, Klein AP
Nature genetics · 2015 · PMID 26098869 · open access

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Pancreatic cancer (rs17688601). MyGeneLog™. https://www.mygenelog.com/variants/rs17688601

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