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GLP-1 levels in response to oral glucose tolerance test (120 minutes)

SLC5A1 · rs17683011

What the study found

Who was studied 3,344 Swedish ancestry individuals; replicated in 4,905 Finnish ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.091 higher (95% confidence interval 0.058-0.124); p = 4 × 10−8.

How common The G allele had a frequency of about 8% in the people studied.

Where it sits Chromosome 22, band 22q12.3 — a missense change in SLC5A1.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of GLP-1 levels in response to oral glucose tolerance test (120 minutes) — no copies of the reported risk allele.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with GLP-1 levels in response to oral glucose tolerance test (120 minutes).
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of GLP-1 levels in response to oral glucose tolerance test (120 minutes) compared to the general population.
Source

Questions about rs17683011

What is rs17683011?

rs17683011 is a single position in the genome, in or near the SLC5A1 gene. Published research associates it with glp-1 levels in response to oral glucose tolerance test (120 minutes). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs17683011 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs17683011 come from?

GWAS Catalog, JCI Insight 2017, PMID:29093273. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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