Standard

Heel bone mineral density

ALPL · rs1767447

Where this position leads

Condition: Heel Bone Mineral Density

rs1767447 Condition: Heel Bone Mineral Density Heel Bone Mineral Density Condition rs1767447 rs1767447 ALPL

What the study found

Who was studied 426,824 British ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.0265 higher (95% confidence interval 0.019-0.034); p = 2 × 10−11.

How common The G allele had a frequency of about 6% in the people studied.

Where it sits Chromosome 1, band 1p36.12 — in an intron of ALPL.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Heel bone mineral density — no copies of the reported risk allele.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Heel bone mineral density.
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Heel bone mineral density compared to the general population.
Source

Questions about rs1767447

What is rs1767447?

rs1767447 is a single position in the genome, in or near the ALPL gene. Published research associates it with heel bone mineral density. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1767447 linked to?

On MyGeneLog this position is linked to Heel Bone Mineral Density. The research behind each link, and its sources, are set out on that condition page.

Does having rs1767447 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1767447 come from?

GWAS Catalog, Nat Genet 2018, PMID:30598549. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Heel bone mineral density (rs1767447). MyGeneLog™. https://www.mygenelog.com/variants/rs1767447

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