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Insomnia symptoms (never/rarely vs. sometimes/usually)

LOC729704 · rs17669584

Where this position leads

Condition: Insomnia

rs17669584 Condition: Insomnia Insomnia Condition rs17669584 rs17669584 LOC729704

What the study found

Who was studied 345,022 European ancestry cases, 108,357 European ancestry controls; replicated in 17,140 European ancestry cases, 61,850 European ancestry controls.

The effect Each copy of the G allele carried 1.03 times the odds of Insomnia symptoms (never/rarely vs. sometimes/usually) (95% confidence interval 1.02-1.05); p = 4 × 10−8.

How common The G allele had a frequency of about 19% in the people studied.

Where it sits Chromosome 17, band 17q11.2 — between genes, 0.8 kb from KRT17P3.

What each result means

A/A No copy of the version the research linked to Insomnia symptoms (never/rarely vs. sometimes/usually). This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Insomnia symptoms (never/rarely vs. sometimes/usually). That is a smaller link than two copies.
G/G Two copies of the version the research linked to Insomnia symptoms (never/rarely vs. sometimes/usually). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs17669584

What is rs17669584?

rs17669584 is a single position in the genome, in or near the LOC729704 gene. Published research associates it with insomnia symptoms (never/rarely vs. sometimes/usually). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs17669584 linked to?

On MyGeneLog this position is linked to Insomnia. The research behind each link, and its sources, are set out on that condition page.

Does having rs17669584 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs17669584 come from?

GWAS Catalog, Nature genetics 2019, PMID:30804566. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Insomnia symptoms (never/rarely vs. sometimes/usually) (rs17669584). MyGeneLog™. https://www.mygenelog.com/variants/rs17669584

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