Standard
Vertical cup-disc ratio
DUSP1 · rs17658229
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What each result means
C/C
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Vertical cup-disc ratio compared to the general population.
C/T
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Vertical cup-disc ratio.
T/T
Published research associates this genotype with typical/baseline likelihood of Vertical cup-disc ratio — no copies of the reported risk allele.
Source
Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process
Springelkamp H,
Höhn R,
Mishra A,
Hysi PG,
Khor CC,
Loomis SJ,
Bailey JN,
Gibson J,
Thorleifsson G,
Janssen SF,
Luo X,
Ramdas WD
and 66 more — show all
Vithana E,
Nongpiur ME,
Montgomery GW,
Xu L,
Mountain JE,
Gharahkhani P,
Lu Y,
Amin N,
Karssen LC,
Sim KS,
van Leeuwen EM,
Iglesias AI,
Verhoeven VJ,
Hauser MA,
Loon SC,
Despriet DD,
Nag A,
Venturini C,
Sanfilippo PG,
Schillert A,
Kang JH,
Landers J,
Jonasson F,
Cree AJ,
van Koolwijk LM,
Rivadeneira F,
Souzeau E,
Jonsson V,
Menon G,
Weinreb RN,
de Jong PT,
Oostra BA,
Uitterlinden AG,
Hofman A,
Ennis S,
Thorsteinsdottir U,
Burdon KP,
Spector TD,
Mirshahi A,
Saw SM,
Vingerling JR,
Teo YY,
Haines JL,
Wolfs RC,
Lemij HG,
Tai ES,
Jansonius NM,
Jonas JB,
Cheng CY,
Aung T,
Viswanathan AC,
Klaver CC,
Craig JE,
Macgregor S,
Mackey DA,
Lotery AJ,
Stefansson K,
Bergen AA,
Young TL,
Wiggs JL,
Pfeiffer N,
Wong TY,
Pasquale LR,
Hewitt AW,
van Duijn CM,
Hammond CJ
Nature communications · 2014 · PMID 25241763 · open access
Questions about rs17658229
What is rs17658229?
rs17658229 is a single position in the genome, in or near the DUSP1 gene. Published research associates it with vertical cup-disc ratio. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs17658229 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs17658229 come from?
GWAS Catalog, Nat Commun 2014, PMID:25241763. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
← See all variants