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Osteoarthritis of the hip or knee

SLC27A6 · rs17615906

Where this position leads

Condition: Osteoarthritis

rs17615906 Condition: Osteoarthritis Osteoarthritis Condition rs17615906 rs17615906 SLC27A6

What the study found

Who was studied 88,842 European ancestry cases, 397,208 European ancestry controls, 899 Japanese ancestry cases, 3,396 Japanese ancestry controls.

The effect Each copy of the T allele carried 0.95 times the odds of Osteoarthritis of the hip or knee (95% confidence interval 0.932047309-0.962493183); p = 4 × 10−11.

How common The T allele had a frequency of about 84% in the people studied.

Where it sits Chromosome 5, band 5q23.3 — in an intron of SLC27A6.

What each result means

C/C No copy of the version the research linked to Osteoarthritis of the hip or knee. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Osteoarthritis of the hip or knee. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Osteoarthritis of the hip or knee. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations
Boer CG, Hatzikotoulas K, Southam L, Stefánsdóttir L, Zhang Y, Coutinho de Almeida R, Wu TT, Zheng J, Hartley A, Teder-Laving M, Skogholt AH, Terao C
and 50 more — show all
Zengini E, Alexiadis G, Barysenka A, Bjornsdottir G, Gabrielsen ME, Gilly A, Ingvarsson T, Johnsen MB, Jonsson H, Kloppenburg M, Luetge A, Lund SH, Mägi R, Mangino M, Nelissen RRGHH, Shivakumar M, Steinberg J, Takuwa H, Thomas LF, Tuerlings M, Babis GC, Cheung JPY, Kang JH, Kraft P, Lietman SA, Samartzis D, Slagboom PE, Stefansson K, Thorsteinsdottir U, Tobias JH, Uitterlinden AG, Winsvold B, Zwart JA, Davey Smith G, Sham PC, Thorleifsson G, Gaunt TR, Morris AP, Valdes AM, Tsezou A, Cheah KSE, Ikegawa S, Hveem K, Esko T, Wilkinson JM, Meulenbelt I, Lee MTM, van Meurs JBJ, Styrkársdóttir U, Zeggini E
arcOGEN Consortium · HUNT All-In Pain · ARGO Consortium · Regeneron Genetics Center
Cell · 2021 · PMID 34450027 · open access

Questions about rs17615906

What is rs17615906?

rs17615906 is a single position in the genome, in or near the SLC27A6 gene. Published research associates it with osteoarthritis of the hip or knee. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs17615906 linked to?

On MyGeneLog this position is linked to Osteoarthritis. The research behind each link, and its sources, are set out on that condition page.

Does having rs17615906 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs17615906 come from?

GWAS Catalog, Cell 2021, PMID:34450027. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Osteoarthritis of the hip or knee (rs17615906). MyGeneLog™. https://www.mygenelog.com/variants/rs17615906

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