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Who was studied 265,204 European ancestry individuals, 7,795 Hispanic individuals, 6,855 East Asian ancestry individuals, 2,958 African American individuals, 439 South Asian ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.021 lower; p = 3 × 10−9.
Where it sits Chromosome 2, band 2q32.1 — in an intron of CALCRL-AS1.
What each result means
C/CNo copy of the version the research linked to High density lipoprotein cholesterol levels. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to High density lipoprotein cholesterol levels. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to High density lipoprotein cholesterol levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2018 · PMID 29507422 · open access
Questions about rs17576323
What is rs17576323?
rs17576323 is a single position in the genome, in or near the near CALCRL gene. Published research associates it with high density lipoprotein cholesterol levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs17576323 linked to?
On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.
Does having rs17576323 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs17576323 come from?
GWAS Catalog, Nat Genet 2018, PMID:29507422. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 191212319Reads by AI crawlersClaude1ChatGPT0Google · Gemini2Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others9Total19Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
High density lipoprotein cholesterol levels (rs17576323). MyGeneLog™. https://www.mygenelog.com/variants/rs17576323