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Low density lipoprotein cholesterol levels

HAVCR1 · rs17573010

Where this position leads

Condition: Cholesterol (LDL, HDL and Total)

What the study found

Who was studied 1,102 Old Order Amish (founder/genetic isolate) individuals; replicated in 798 Old Order Amish (founder/genetic isolate) individuals.

The effect Each copy of the G allele shifted the measure 13.1 mg/dL higher (95% confidence interval -); p = 9 × 10⁻¹⁰.

Where it sits Chromosome 5, band 5q33.3 — in an intron of HAVCR1.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Low density lipoprotein cholesterol levels — no copies of the reported risk allele.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Low density lipoprotein cholesterol levels.

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Low density lipoprotein cholesterol levels compared to the general population.

Source

An APOO Pseudogene on Chromosome 5q Is Associated With Low-Density Lipoprotein Cholesterol Levels

Montasser ME, O'Hare EA, Wang X, Howard AD, McFarland R, Perry JA, Ryan KA, Rice K, Jaquish CE, Shuldiner AR, Miller M, Mitchell BD

and 2 more — show all

Zaghloul NA, Chang YC

Circulation · 2018 · PMID 29593015

Questions about rs17573010

What is rs17573010?

rs17573010 is a single position in the genome, in or near the HAVCR1 gene. Published research associates it with low density lipoprotein cholesterol levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs17573010 linked to?

On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.

Does having rs17573010 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs17573010 come from?

GWAS Catalog, Circulation 2018, PMID:29593015. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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