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Standard

Height

IGFALS · rs17559

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10−11, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 293,593 African ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0217 lower (95% confidence interval 0.015-0.028); p = 2 × 10−11.

How common The A allele had a frequency of about 41% in the people studied.

Where it sits Chromosome 16, band 16p13.3 — a synonymous change in IGFALS.

What ClinVar records

Classification Benign for Short stature due to primary acid-labile subunit deficiency; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 4 submitters), last evaluated 2026-05-08. ClinVar record 318241 NM_004970.3(IGFALS):c.1386C>T (p.Tyr462=)

Change history MyGeneLog™ keeps a copy of every weekly release from 2026-10-19 and compares them. This position's classification has not changed since.

What this is ClinVar's aggregate record for this position (as of its 2026-11-01 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

How common each version is

AG
Korean KRGDB
A 14.1% · G 85.9%
Korean Korea4K
A 13.4% · G 86.7%
Korean Korea1K
A 13.4% · G 86.6%
Japanese ToMMo
A 10.5% · G 89.5%
Vietnamese
A 13.0% · G 87.0%
World gnomAD
A 20.1% · G 79.9%
World 1000 Genomes
A 25.6% · G 74.4%
World TOPMed
A 20.7% · G 79.3%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

A/A Two copies of the version the research linked to Height. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Height. That is a smaller link than two copies.
G/G No copy of the version the research linked to Height. This is the starting point the study compared everyone against.
Source

Quoting this page

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Height (rs17559). MyGeneLog™. https://www.mygenelog.com/variants/rs17559

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