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Its strongest genetic-study result is p = 10−23, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 5,314,291 European ancestry, Hispanic or Latin American, East Asian ancestry, African ancestry, South Asian ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.009 higher (95% confidence interval 0.0072-0.0108); p = 1 × 10−23.
How common The T allele had a frequency of about 21% in the people studied.
Where it sits Chromosome 18, band 18p11.32 — in an intron of SMCHD1.
What ClinVar records
ClassificationBenign; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 2 submitters), last evaluated 2021-03-24.
ClinVar record 1232176NM_015295.3(SMCHD1):c.5547+145C>T
Change history
MyGeneLog™ keeps a copy of every weekly release from 2026-10-19 and compares them. This position's classification has not changed since.
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
C/CNo copy of the version the research linked to Height. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Height. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Height. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs17552342 is a single position in the genome, in or near the SMCHD1 gene. Published research associates it with height. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs17552342 linked to?
On MyGeneLog this position is linked to Height. The research behind each link, and its sources, are set out on that condition page.
Does having rs17552342 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs17552342 come from?
GWAS Catalog, Nature 2022, PMID:36224396. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 7124Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot1Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others4Total7Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license