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Who was studied 4,831 European ancestry cases, 115,455 European ancestry controls; replicated in up to 60,801 European and unknown ancestry cases, up to 123,504 European and unknown ancestry controls.
The effect
Each copy of the C allele carried 1.06 times the odds of Coronary artery disease (95% confidence interval 1.04-1.08); p = 1 × 10−8.
How common The C allele had a frequency of about 75% in the people studied.
Where it sits Chromosome 2, band 2q35 — in an intron of FN1.
What each result means
C/CTwo copies of the version the research linked to Coronary artery disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Coronary artery disease. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Coronary artery disease. This is the starting point the study compared everyone against.
Nature genetics · 2017 · PMID 28714974 · open access
Questions about rs17517928
What is rs17517928?
rs17517928 is a single position in the genome, in or near the FN1 gene. Published research associates it with coronary artery disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs17517928 linked to?
On MyGeneLog this position is linked to Coronary Artery Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs17517928 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs17517928 come from?
GWAS Catalog, Nature genetics 2017, PMID:28714974. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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