0 15141225Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI4Microsoft · Copilot1Amazon2Apple0China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others5Total15Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 122,644 European ancestry individuals (MTAG effective sample size boosted by proton density fat fraction samples).
The effect
Each copy of the G allele shifted the measure 0.109 higher (95% confidence interval 0.086-0.131); p = 3 × 10−21.
How common The G allele had a frequency of about 96% in the people studied.
Where it sits Chromosome 11, band 11q23.3 — in an intron of SIK3.
What each result means
A/ANo copy of the version the research linked to Metabolic dysfunction-associated steatotic liver disease (MTAG). This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Metabolic dysfunction-associated steatotic liver disease (MTAG). That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Metabolic dysfunction-associated steatotic liver disease (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
Science advances · 2026 · PMID 41686896 · open access
Questions about rs17496758
What is rs17496758?
rs17496758 is a single position in the genome, in or near the SIK3 gene. Published research associates it with metabolic dysfunction-associated steatotic liver disease (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs17496758 linked to?
On MyGeneLog this position is linked to Nonalcoholic Fatty Liver Disease (NAFLD). The research behind each link, and its sources, are set out on that condition page.
Does having rs17496758 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs17496758 come from?
GWAS Catalog, Science advances 2026, PMID:41686896. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 15141225Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI4Microsoft · Copilot1Amazon2Apple0China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others5Total15Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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